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ARNT aryl hydrocarbon receptor nuclear translocator [ Homo sapiens (human) ]

Gene ID: 405, updated on 2-Nov-2024

Summary

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Official Symbol
ARNTprovided by HGNC
Official Full Name
aryl hydrocarbon receptor nuclear translocatorprovided by HGNC
Primary source
HGNC:HGNC:700
See related
Ensembl:ENSG00000143437 MIM:126110; AllianceGenome:HGNC:700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARNT1; HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta
Summary
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
Expression
Ubiquitous expression in ovary (RPKM 16.9), placenta (RPKM 14.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See ARNT in Genome Data Viewer
Location:
1q21.3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (150809713..150876599, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149933391..150000287, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150782189..150849075, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene short coiled-coil protein pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150753350-150754207 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:150754208-150755064 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150766964 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150774101 Neighboring gene ubiquitin conjugating enzyme E2 D3 pseudogene 3 Neighboring gene cathepsin K Neighboring gene RNA, U6 small nuclear 1309, pseudogene Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150800090 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150800655 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150808889 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150818234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:150822359-150823012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:150823013-150823665 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150825511 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150826831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150846639-150847140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:150847141-150847640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1306 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:150849134-150849407 Neighboring gene uncharacterized LOC107985204 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150856806 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150858571 Neighboring gene RPS27A pseudogene 6 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150864113 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 1:150864992 Neighboring gene cortexin domain containing 2 Neighboring gene CYCS pseudogene 51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Mandl M, et al. Radiat Oncol, 2015 Nov 16. PMID 26572229, Free PMC Article
  2. The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription. Brunnberg S, et al. Proc Natl Acad Sci U S A, 2003 May 27. PMID 12754377, Free PMC Article
  3. The aryl hydrocarbon receptor nuclear translocator (ARNT) modulates the antioxidant response in AML cells. Gu C, et al. Leuk Res, 2013 Dec. PMID 24220583
  4. Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein. Wilson CL, et al. Arch Biochem Biophys, 1997 Oct 1. PMID 9328285
  5. The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations. Wang XW, et al. Br J Dermatol, 2012 May. PMID 22211302

See all (311) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
    Title: Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.
  2. Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
    Title: Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
  3. Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1beta.
    Title: Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β.
  4. AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity.
    Title: AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity.
  5. The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis.
    Title: The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis.
  6. Hypoxia-inducible factor-1beta is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts.
    Title: Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts.
  7. GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion.
    Title: GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion.
  8. The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.
    Title: The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor.
  9. Detrimental effects of hypoxia on glomerular podocytes.
    Title: Detrimental effects of hypoxia on glomerular podocytes.
  10. Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.
    Title: Transethnic associations among immune-mediated diseases and single-nucleotide polymorphisms of the aryl hydrocarbon response gene ARNT and the PTPN22 immune regulatory gene.
Submit: New GeneRIF Correction See all GeneRIFs (113)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3.
EBI GWAS Catalog
Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA downregulates ARNT gene expression in HepG2 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to nuclear receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
  
involved_in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation IC
Inferred by Curator
more info
 PubMed 
involved_in positive regulation of erythrocyte differentiation IC
Inferred by Curator
more info
  
acts_upstream_of positive regulation of glycolytic process IDA
Inferred from Direct Assay
more info
  
involved_in positive regulation of hormone biosynthetic process IDA
Inferred from Direct Assay
more info
  
involved_in positive regulation of protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of aryl hydrocarbon receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear aryl hydrocarbon receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aryl hydrocarbon receptor nuclear translocator
Names
class E basic helix-loop-helix protein 2
dioxin receptor, nuclear translocator
hypoxia inducible factor 1 subunit beta
hypoxia-inducible factor 1, beta subunit

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028248.1 RefSeqGene

    Range
    5170..72056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001197325.2 → NP_001184254.1  aryl hydrocarbon receptor nuclear translocator isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK291705, AL355860, BU730937
    UniProtKB/TrEMBL
    A8K6P0
    Conserved Domains (5) summary
    smart00091
    Location:151 → 215
    PAS; PAS domain
    cd00130
    Location:347 → 443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:76 → 128
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:148 → 254
    PAS; PAS fold
    pfam14598
    Location:347 → 447
    PAS_11; PAS domain

  2. NM_001286035.2 → NP_001272964.1  aryl hydrocarbon receptor nuclear translocator isoform 5

    See identical proteins and their annotated locations for NP_001272964.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' region, initiates translation at a downstream in-frame start codon, and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AK223459, AK293027, AL355860, AL834279, BU730937
    Consensus CDS
    CCDS65641.1
    UniProtKB/TrEMBL
    B0AZM1
    Related
    ENSP00000423851.1, ENST00000515192.5
    Conserved Domains (6) summary
    smart00091
    Location:157 → 221
    PAS; PAS domain
    cd00130
    Location:348 → 444
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:82 → 134
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:154 → 260
    PAS; PAS fold
    pfam11593
    Location:509 → 720
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:348 → 448
    PAS_11; PAS domain

  3. NM_001286036.2 → NP_001272965.1  aryl hydrocarbon receptor nuclear translocator isoform 6

    See identical proteins and their annotated locations for NP_001272965.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AB209877, AK223459, AK293027, AL355860, BU730937
    Consensus CDS
    CCDS65642.1
    UniProtKB/TrEMBL
    B0AZM1
    Related
    ENSP00000346372.2, ENST00000354396.6
    Conserved Domains (3) summary
    cd18947
    Location:86 → 150
    bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
    pfam00989
    Location:163 → 269
    PAS; PAS fold
    pfam14598
    Location:362 → 462
    PAS_11; PAS domain

  4. NM_001350224.2 → NP_001337153.1  aryl hydrocarbon receptor nuclear translocator isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate exon in the 5' region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (7) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK293027, AL355860, BC041121, BU730937
    UniProtKB/TrEMBL
    B0AZM1
    Conserved Domains (4) summary
    pfam00010
    Location:82 → 134
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:154 → 260
    PAS; PAS fold
    pfam11593
    Location:514 → 725
    Med3; Mediator complex subunit 3 fungal
    cl25986
    Location:353 → 453
    PAS_3; PAS fold

  5. NM_001350225.2 → NP_001337154.1  aryl hydrocarbon receptor nuclear translocator isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in its 5' coding region, resulting in the use of an alternate start codon, compared to variant 1. The encoded isoform (8) has a slightly shorter, but distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK293027, AL355860, BC041121, BU730937
    UniProtKB/TrEMBL
    B4E3L5
    Conserved Domains (4) summary
    pfam00010
    Location:90 → 142
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:162 → 268
    PAS; PAS fold
    pfam11593
    Location:522 → 733
    Med3; Mediator complex subunit 3 fungal
    cl25986
    Location:361 → 461
    PAS_3; PAS fold

  6. NM_001350226.2 → NP_001337155.1  aryl hydrocarbon receptor nuclear translocator isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses an alternate splice site in its 5' coding region, resulting in the use of an alternate start codon, compared to variant 1. The encoded isoform (8) has a slightly shorter, but distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK293027, AL355860, BC041121, BU730937
    UniProtKB/TrEMBL
    B4E3L5
    Conserved Domains (4) summary
    pfam00010
    Location:89 → 141
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:161 → 267
    PAS; PAS fold
    pfam11593
    Location:521 → 732
    Med3; Mediator complex subunit 3 fungal
    cl25986
    Location:360 → 460
    PAS_3; PAS fold

  7. NM_001668.4 → NP_001659.1  aryl hydrocarbon receptor nuclear translocator isoform 1

    See identical proteins and their annotated locations for NP_001659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK293027, AL355860, BC041121, BU730937
    Consensus CDS
    CCDS970.1
    UniProtKB/Swiss-Prot
    B2R9H1, C4AMA1, F8WAP6, P27540, Q59ED4, Q5QP39, Q8NDC7
    UniProtKB/TrEMBL
    B0AZM1
    Related
    ENSP00000351407.5, ENST00000358595.10
    Conserved Domains (6) summary
    smart00091
    Location:166 → 230
    PAS; PAS domain
    cd00130
    Location:362 → 458
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:91 → 143
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:163 → 269
    PAS; PAS fold
    pfam11593
    Location:523 → 734
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:362 → 462
    PAS_11; PAS domain

  8. NM_178427.3 → NP_848514.1  aryl hydrocarbon receptor nuclear translocator isoform 3

    See identical proteins and their annotated locations for NP_848514.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK315812, AL355860, BU730937
    Consensus CDS
    CCDS971.1
    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
    Related
    ENSP00000427571.1, ENST00000505755.5
    Conserved Domains (6) summary
    smart00091
    Location:151 → 215
    PAS; PAS domain
    cd00130
    Location:347 → 443
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:76 → 128
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:148 → 254
    PAS; PAS fold
    pfam11593
    Location:508 → 719
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:347 → 447
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    150809713..150876599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420740.1 → XP_047276696.1  aryl hydrocarbon receptor nuclear translocator isoform X29

  2. XM_047420734.1 → XP_047276690.1  aryl hydrocarbon receptor nuclear translocator isoform X28

  3. XM_047420716.1 → XP_047276672.1  aryl hydrocarbon receptor nuclear translocator isoform X20

  4. XM_047420715.1 → XP_047276671.1  aryl hydrocarbon receptor nuclear translocator isoform X19

  5. XM_047420727.1 → XP_047276683.1  aryl hydrocarbon receptor nuclear translocator isoform X27

  6. XM_017001296.2 → XP_016856785.1  aryl hydrocarbon receptor nuclear translocator isoform X26

    UniProtKB/TrEMBL
    A8K6P0

  7. XM_047420719.1 → XP_047276675.1  aryl hydrocarbon receptor nuclear translocator isoform X25

  8. XM_017001295.2 → XP_016856784.1  aryl hydrocarbon receptor nuclear translocator isoform X24

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1

  9. XM_047420711.1 → XP_047276667.1  aryl hydrocarbon receptor nuclear translocator isoform X16

  10. XM_005245153.2 → XP_005245210.1  aryl hydrocarbon receptor nuclear translocator isoform X15

    UniProtKB/TrEMBL
    B0AZM1
    Conserved Domains (6) summary
    smart00091
    Location:166 → 230
    PAS; PAS domain
    cd00130
    Location:357 → 453
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:91 → 143
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:163 → 269
    PAS; PAS fold
    pfam11593
    Location:518 → 729
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:357 → 457
    PAS_11; PAS domain

  11. XM_017001294.2 → XP_016856783.1  aryl hydrocarbon receptor nuclear translocator isoform X23

    UniProtKB/TrEMBL
    A8K6P0

  12. XM_005245157.2 → XP_005245214.1  aryl hydrocarbon receptor nuclear translocator isoform X22

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1
    Conserved Domains (6) summary
    smart00091
    Location:166 → 230
    PAS; PAS domain
    cd00130
    Location:362 → 458
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:91 → 143
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:163 → 269
    PAS; PAS fold
    pfam11593
    Location:486 → 697
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:362 → 462
    PAS_11; PAS domain

  13. XM_005245151.3 → XP_005245208.1  aryl hydrocarbon receptor nuclear translocator isoform X12

    UniProtKB/TrEMBL
    A8K6P0
    Conserved Domains (5) summary
    smart00091
    Location:166 → 230
    PAS; PAS domain
    cd00130
    Location:362 → 458
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:91 → 143
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:163 → 269
    PAS; PAS fold
    pfam14598
    Location:362 → 462
    PAS_11; PAS domain

  14. XM_047420697.1 → XP_047276653.1  aryl hydrocarbon receptor nuclear translocator isoform X7

  15. XM_047420694.1 → XP_047276650.1  aryl hydrocarbon receptor nuclear translocator isoform X6

  16. XM_017001293.2 → XP_016856782.1  aryl hydrocarbon receptor nuclear translocator isoform X11

    UniProtKB/TrEMBL
    A8K6P0

  17. XM_047420701.1 → XP_047276657.1  aryl hydrocarbon receptor nuclear translocator isoform X10

  18. XM_017001291.2 → XP_016856780.1  aryl hydrocarbon receptor nuclear translocator isoform X5

    UniProtKB/TrEMBL
    A8K6P0

  19. XM_017001290.3 → XP_016856779.1  aryl hydrocarbon receptor nuclear translocator isoform X4

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1

  20. XM_047420692.1 → XP_047276648.1  aryl hydrocarbon receptor nuclear translocator isoform X3

  21. XM_017001289.2 → XP_016856778.1  aryl hydrocarbon receptor nuclear translocator isoform X2

    UniProtKB/TrEMBL
    B0AZM1
    Conserved Domains (6) summary
    smart00091
    Location:157 → 221
    PAS; PAS domain
    cd00130
    Location:348 → 444
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:82 → 134
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:154 → 260
    PAS; PAS fold
    pfam11593
    Location:509 → 720
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:348 → 448
    PAS_11; PAS domain

  22. XM_047420700.1 → XP_047276656.1  aryl hydrocarbon receptor nuclear translocator isoform X9

  23. XM_017001292.2 → XP_016856781.1  aryl hydrocarbon receptor nuclear translocator isoform X8

    UniProtKB/TrEMBL
    A8K6P0, B0AZM1

  24. XM_017001288.3 → XP_016856777.1  aryl hydrocarbon receptor nuclear translocator isoform X1

    UniProtKB/TrEMBL
    A8K6P0

  25. XM_047420713.1 → XP_047276669.1  aryl hydrocarbon receptor nuclear translocator isoform X18

  26. XM_047420709.1 → XP_047276665.1  aryl hydrocarbon receptor nuclear translocator isoform X14

  27. XM_047420743.1 → XP_047276699.1  aryl hydrocarbon receptor nuclear translocator isoform X30

  28. XM_047420712.1 → XP_047276668.1  aryl hydrocarbon receptor nuclear translocator isoform X17

  29. XM_011509543.4 → XP_011507845.1  aryl hydrocarbon receptor nuclear translocator isoform X13

    See identical proteins and their annotated locations for XP_011507845.1

    UniProtKB/TrEMBL
    B4E3L5
    Conserved Domains (4) summary
    pfam00010
    Location:90 → 142
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:162 → 268
    PAS; PAS fold
    pfam11593
    Location:522 → 733
    Med3; Mediator complex subunit 3 fungal
    cl25986
    Location:361 → 461
    PAS_3; PAS fold

  30. XM_011509546.3 → XP_011507848.1  aryl hydrocarbon receptor nuclear translocator isoform X21

    UniProtKB/TrEMBL
    B0AZM1
    Conserved Domains (6) summary
    smart00091
    Location:134 → 198
    PAS; PAS domain
    cd00130
    Location:330 → 426
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:59 → 111
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:131 → 237
    PAS; PAS fold
    pfam11593
    Location:491 → 702
    Med3; Mediator complex subunit 3 fungal
    pfam14598
    Location:330 → 430
    PAS_11; PAS domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    149933391..150000287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336623.1 → XP_054192598.1  aryl hydrocarbon receptor nuclear translocator isoform X29

  2. XM_054336622.1 → XP_054192597.1  aryl hydrocarbon receptor nuclear translocator isoform X28

  3. XM_054336614.1 → XP_054192589.1  aryl hydrocarbon receptor nuclear translocator isoform X20

  4. XM_054336613.1 → XP_054192588.1  aryl hydrocarbon receptor nuclear translocator isoform X19

  5. XM_054336621.1 → XP_054192596.1  aryl hydrocarbon receptor nuclear translocator isoform X27

  6. XM_054336620.1 → XP_054192595.1  aryl hydrocarbon receptor nuclear translocator isoform X26

  7. XM_054336619.1 → XP_054192594.1  aryl hydrocarbon receptor nuclear translocator isoform X25

  8. XM_054336618.1 → XP_054192593.1  aryl hydrocarbon receptor nuclear translocator isoform X24

  9. XM_054336610.1 → XP_054192585.1  aryl hydrocarbon receptor nuclear translocator isoform X16

  10. XM_054336609.1 → XP_054192584.1  aryl hydrocarbon receptor nuclear translocator isoform X15

  11. XM_054336617.1 → XP_054192592.1  aryl hydrocarbon receptor nuclear translocator isoform X23

  12. XM_054336616.1 → XP_054192591.1  aryl hydrocarbon receptor nuclear translocator isoform X22

  13. XM_054336608.1 → XP_054192583.1  aryl hydrocarbon receptor nuclear translocator isoform X12

  14. XM_054336603.1 → XP_054192578.1  aryl hydrocarbon receptor nuclear translocator isoform X7

  15. XM_054336602.1 → XP_054192577.1  aryl hydrocarbon receptor nuclear translocator isoform X6

  16. XM_054336607.1 → XP_054192582.1  aryl hydrocarbon receptor nuclear translocator isoform X11

  17. XM_054336606.1 → XP_054192581.1  aryl hydrocarbon receptor nuclear translocator isoform X10

  18. XM_054336601.1 → XP_054192576.1  aryl hydrocarbon receptor nuclear translocator isoform X5

  19. XM_054336600.1 → XP_054192575.1  aryl hydrocarbon receptor nuclear translocator isoform X4

  20. XM_054336599.1 → XP_054192574.1  aryl hydrocarbon receptor nuclear translocator isoform X3

  21. XM_054336598.1 → XP_054192573.1  aryl hydrocarbon receptor nuclear translocator isoform X2

  22. XM_054336605.1 → XP_054192580.1  aryl hydrocarbon receptor nuclear translocator isoform X9

  23. XM_054336604.1 → XP_054192579.1  aryl hydrocarbon receptor nuclear translocator isoform X8

  24. XM_054336597.1 → XP_054192572.1  aryl hydrocarbon receptor nuclear translocator isoform X1

  25. XM_054336612.1 → XP_054192587.1  aryl hydrocarbon receptor nuclear translocator isoform X18

  26. XM_054336624.1 → XP_054192599.1  aryl hydrocarbon receptor nuclear translocator isoform X30

  27. XM_054336611.1 → XP_054192586.1  aryl hydrocarbon receptor nuclear translocator isoform X17

  28. XM_054336615.1 → XP_054192590.1  aryl hydrocarbon receptor nuclear translocator isoform X21

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178426.1: Suppressed sequence

    Description
    NM_178426.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27540.1 GenPept UniProtKB/Swiss-Prot:P27540

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